In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.

WIN 51711 (5-[7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3-methylisoxazole), a new antipicornavirus drug, is a potent inhibitor of human entero- and rhinoviruses at concentrations not inhibitory to HeLa cell growth. In plaque reduction assays, WIN 51711 reduced plaque formation by 9 enteroviruses and 33 rhinoviruses, with MICs of 0.004 to 0.17 and 0.004 to 6.2 micrograms/ml, respectively. Addition of WIN 51711 to infected cells at concentrations of 0.02 to 5.0 micrograms/ml reduced the yield of picornaviruses by 90%. Other RNA viruses (nonpicornaviruses) and DNA viruses were unaffected by the compound.

Citation

M J Otto, M P Fox, M J Fancher, M F Kuhrt, G D Diana, M A McKinlay. In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug. Antimicrobial agents and chemotherapy. 1985 Jun;27(6):883-6

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PMID: 2992365

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