Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

Ioannis D Dimitriou, Korris Lee, Itoro Akpan, Evan F Lind, Valarie A Barr, Pamela S Ohashi, Lawrence E Samelson, Robert Rottapel

Cell reports 2018 Jul 31

filter terms:

Successful anti-viral response requires the sustained activation and expansion of CD8+ T cells for periods that far exceed the time limit of physical T cell interaction with antigen-presenting cells (APCs). The expanding CD8+ T cell pool generates the effector and memory cell populations that provide viral clearance and long-term immunity, respectively. Here, we demonstrate that 3BP2 is recruited in cytoplasmic microclusters and nucleates a signaling complex that facilitates MHC:peptide-independent activation of signaling pathways downstream of the TCR. We show that induction of the adaptor molecule 3BP2 is a sensor of TCR signal strength and is critical for sustaining CD8+ T cell proliferation and regulating effector and memory differentiation. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Citation

Ioannis D Dimitriou, Korris Lee, Itoro Akpan, Evan F Lind, Valarie A Barr, Pamela S Ohashi, Lawrence E Samelson, Robert Rottapel. Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation. Cell reports. 2018 Jul 31;24(5):1123-1135