Correlation Engine 2.0
Clear Search sequence regions


  • autism (9)
  • autoantibodies (1)
  • brain (1)
  • factors (5)
  • factors sex (1)
  • female (1)
  • fetal proteins (3)
  • humans (1)
  • pregnancy (2)
  • sex (3)
  • sex differences (1)
  • Sizes of these terms reflect their relevance to your search.

    While genetic factors are a major etiological contributor to autism spectrum disorder (ASD), evidence also supports a role for environmental factors. Herein, we will discuss two such factors that have been associated with a significant proportion of ASD risk: prenatal stress exposure and maternal immune dysregulation, and how sex and gender relate to these factors. Recent evidence suggests that maternal stress susceptibility interacts with prenatal stress exposure to affect offspring neurodevelopment. Additionally, understanding of the impact of maternal immune dysfunction on ASD has recently been advanced by recognition of specific fetal brain proteins targeted by maternal autoantibodies, and identification of unique mid-gestational maternal immune profiles. Animal models have been developed to explore pathophysiology targeting both of these factors, with limited sex-specific effects observed. While prenatal stress and maternal immune dysregulation are associated with ASD, most cases of these prenatal exposures do not result in ASD, suggesting interaction with multiple other risks. We are beginning to understand the behavioral, pharmacopathological, and epigenetic effects related to these interactions, as well as potential mitigating factors. Sex differences of these risks have been understudied but are crucial for understanding the higher prevalence of ASD in boys. Continued growth in understanding of these mechanisms may ultimately allow for the identification of multiple potential points for prevention or intervention, and for a personalized medicine approach for this subset of environmental-associated ASD cases.

    Citation

    David Q Beversdorf, Hanna E Stevens, Karen L Jones. Prenatal Stress, Maternal Immune Dysregulation, and Their Association With Autism Spectrum Disorders. Current psychiatry reports. 2018 Aug 09;20(9):76

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 30094645

    View Full Text