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Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin-7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms (SNPs) on interleukin-7 gene and the risk of children asthma. We genotyped eight SNPs of interleukin-7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these SNPs with the risk of asthma in children. A missense SNP rs766736182 (odds ratio (OR) = 2.185, 95% confidence interval (CI) = 1.561-2.252, P-value = 8.69468E-19) of the interleukin-7 gene is associated with the risk of children asthma. This study reveals that SNP rs766736182 of interleukin-7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma. © 2018 Wiley Periodicals, Inc.


Junhua Cao, Lijun Tian, Zhenguang Li, Chonglin Zhang, Qiang Ji, Chuanling Zhang, Tong Qian. Interleukin-7 gene polymorphism rs766736182 associates with the risk of asthma in children. Journal of clinical laboratory analysis. 2019 Feb;33(2):e22675

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PMID: 30239047

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