Interleukin-7 gene polymorphism rs766736182 associates with the risk of asthma in children.

Junhua Cao, Lijun Tian, Zhenguang Li, Chonglin Zhang, Qiang Ji, Chuanling Zhang, Tong Qian

Journal of clinical laboratory analysis 2019 Feb

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Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin-7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms (SNPs) on interleukin-7 gene and the risk of children asthma. We genotyped eight SNPs of interleukin-7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these SNPs with the risk of asthma in children. A missense SNP rs766736182 (odds ratio (OR) = 2.185, 95% confidence interval (CI) = 1.561-2.252, P-value = 8.69468E-19) of the interleukin-7 gene is associated with the risk of children asthma. This study reveals that SNP rs766736182 of interleukin-7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma. © 2018 Wiley Periodicals, Inc.

Citation

Junhua Cao, Lijun Tian, Zhenguang Li, Chonglin Zhang, Qiang Ji, Chuanling Zhang, Tong Qian. Interleukin-7 gene polymorphism rs766736182 associates with the risk of asthma in children. Journal of clinical laboratory analysis. 2019 Feb;33(2):e22675