Alessandro Scopelliti, Christin Bauer, Yachuan Yu, Tong Zhang, Björn Kruspig, Daniel J Murphy, Marcos Vidal, Oliver D K Maddocks, Julia B Cordero
Cell metabolism 2019 Feb 05The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges. The mechanisms driving such programs are largely unknown. Here, we show that enteroendocrine cells in the adult Drosophila intestine respond to nutrients by secreting the hormone Bursicon α, which signals via its neuronal receptor DLgr2. Bursicon α/DLgr2 regulate energy metabolism through a neuronal relay leading to the restriction of glucagon-like, adipokinetic hormone (AKH) production by the corpora cardiaca and subsequent modulation of AKH receptor signaling within the adipose tissue. Impaired Bursicon α/DLgr2 signaling leads to exacerbated glucose oxidation and depletion of energy stores with consequent reduced organismal resistance to nutrient restrictive conditions. Altogether, our work reveals an intestinal/neuronal/adipose tissue inter-organ communication network that is essential to restrict the use of energy and that may provide insights into the physiopathology of endocrine-regulated metabolic homeostasis. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
Alessandro Scopelliti, Christin Bauer, Yachuan Yu, Tong Zhang, Björn Kruspig, Daniel J Murphy, Marcos Vidal, Oliver D K Maddocks, Julia B Cordero. A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila. Cell metabolism. 2019 Feb 05;29(2):269-284.e10
PMID: 30344016
View Full Text