Prostate-Specific Membrane Antigen-Positive Manifestations of Chronic Beryllium Lung Disease.

Kai Huang, Alexander Dj Baur, Christian Furth

Clinical nuclear medicine 2019 Jan

filter terms:

Three years after prostatectomy, a 78-year-old man with initial high-risk prostate cancer and new increasing prostate-specific antigen levels underwent Ga-prostate-specific membrane antigen (PSMA) PET/CT. Imaging revealed PSMA-positive pelvic, ascending retroperitoneal and left supraclavicular lymph nodes consistent with metastases. Additionally, there was PSMA-positive lymphadenopathy (hilar and mediastinal) and pulmonary changes (fibrotic and nodular) in which histopathology excluded metastases. A lymphocyte proliferation test was indicative of beryllium sensitization. Chronic beryllium lung disease-a multisystem granulomatous inflammatory disease mainly affecting the lungs-could be established in this patient with occupational exposure to beryllium. This case shows that manifestations of berylliosis can also be PSMA positive.

Citation

Kai Huang, Alexander Dj Baur, Christian Furth. Prostate-Specific Membrane Antigen-Positive Manifestations of Chronic Beryllium Lung Disease. Clinical nuclear medicine. 2019 Jan;44(1):64-65