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Malaria parasite oocysts located on the mosquito midgut generate sporozoites by a process called sporogony. Plasmodium berghei parasites express six LCCL lectin domain adhesive-like proteins (LAPs), which operate as a complex and share a localisation in the crystalloid - an organelle found in the ookinete and young oocyst. Depletion of LAPs prevents crystalloid formation, increases oocyst growth, and blocks sporogony. Here, we describe a LAP4 mutant that has abnormal crystalloid biogenesis and produces oocysts that display reduced growth and premature sporogony. These findings provide evidence for a role of the LAP complex in regulating oocyst cell division via the crystalloid. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

Sadia Saeed, Annie Z Tremp, Johannes T Dessens. The Plasmodium LAP complex affects crystalloid biogenesis and oocyst cell division. International journal for parasitology. 2018 Dec;48(14):1073-1078

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PMID: 30367865

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