Clear Search sequence regions


  • acid (1)
  • alkaloids (3)
  • biflavonoids (3)
  • herbal (2)
  • mass (4)
  • mass behavior (1)
  • phase (1)
  • phenols (3)
  • research (1)
  • rheumatoid arthritis (1)
  • sesquiterpenes (3)
  • wen (6)
  • Sizes of these terms reflect their relevance to your search.

    Wen Luo Yin (WLY), a well-known traditional Chinese medicine formulation, has been used as a complementary therapy for the treatment of rheumatoid arthritis in clinical settings. However, the chemical constituents of WLY remain unclear. In this study, a high-performance liquid chromatography coupled with tandem mass spectrometry method was established to separate and comprehensively identify the chemical constituents of WLY. The analytes were eluted with a mobile phase of acetonitrile and 0.1% aqueous acetic acid. Mass detection was performed in both positive and negative ion mode. The MS/MS fragmentation pathways were proposed for the identification of the components. A total of 42 compounds including sesquiterpenes, alkaloids, biflavonoids, polyacetylenes, phenylpropanoids and acetylenic phenols were identified unambiguously or tentatively according to their retention times and mass behavior with those of authentic standards or literature data. The identification and structural elucidation of chemical constituents may provide important information for quality control and pharmacological research of WLY.

    Citation

    Huanyu Guan, Xiaomei Luo, Xiaoyan Chang, Meifeng Su, Zhuangzhuang Li, Pengfei Li, Xiaoming Wang, Yue Shi. Identification of the Chemical Constituents of an Anti-Arthritic Chinese Medicine Wen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry. Molecules (Basel, Switzerland). 2019 Jan 10;24(2)

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 30634574

    View Full Text