Isolated Antenatal Hydrocephalus After Fetal Exposure to Misoprostol: Teratogenic Effect of the Cytotec?

Misoprostol is often used for termination of pregnancy in France and other countries. However, some pregnancies are continued after taking the drug and congenital malformations are known to be the consequence of fetal exposure to misoprostol, among them hydrocephalus. The type of hydrocephalus in case of misoprostol exposure is not known. We report the first case in the literature of an obstructive hydrocephalus due to an aqueduct of Sylvius stenosis diagnosed during pregnancy after misoprostol intake. The possible physiopathologic implications of the drug regarding the genesis of this malformation are discussed. Copyright © 2019 Elsevier Inc. All rights reserved.

Citation

Pierre-Aurelien Beuriat, Lucile Cattiaux, Laurent Guibaud, Alexandru Szathmari, Isabelle Sabatier, Christophe Rousselle, Carmine Mottolese, Federico Di Rocco. Isolated Antenatal Hydrocephalus After Fetal Exposure to Misoprostol: Teratogenic Effect of the Cytotec? World neurosurgery. 2019 Apr;124:98-100

PMID: 30639481

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