A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient.

Ma Liang, Zhang Liwen, Dai Juan, Zhuang Yun, Ding Yanbo, Chen Jianping

Medicine 2019 Jan

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Fungal infection of gastrointestinal (GI) tract is usually seen in immunocompromised patients, but can rarely occur in immunocompetent people in whom no permissive factor is present. We describe a 68-year-old male immunocompetent patient presenting with simultaneous fungal esophagitis and giant gastric ulcer. Repeated endoscopic biopsies were taken from the giant gastric ulcer edge and base and histology demonstrated granulation tissue and pseudohyphal fungal forms. The patient was treated with fluconazole and omeprazole for 8 weeks. After antifungal treatment with fluconazole, the patient's clinical symptoms gradually disappeared with the healing of gastric ulcer, which never recurred in this patient until 3 months after follow-up. Nonhealing gastroesophageal ulcers highlights the importance of repeated endoscopies and biopsies.

Citation

Ma Liang, Zhang Liwen, Dai Juan, Zhuang Yun, Ding Yanbo, Chen Jianping. A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient. Medicine. 2019 Jan;98(3):e14158