Eduardo J E Caro-Diaz, Frederick A Valeriote, William H Gerwick
Organic letters 2019 Feb 01The total synthesis of majusculamide D (MJS-D) is described, a lipopentapeptide originally isolated from Lyngbya majuscula and reisolated from a Moorea sp. MJS-D possesses selective and potent cancer cell toxicity. A scalable and convergent strategy with a minimal number of purifications produced significant quantities of MJM-D for in vivo evaluations. The absolute configuration of the 1,3-dimethyl-octanamide motif was determined by synthesis of this fragment via ZACA chemistry.
Eduardo J E Caro-Diaz, Frederick A Valeriote, William H Gerwick. Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp. Organic letters. 2019 Feb 01;21(3):793-796
PMID: 30673235
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