Regulatory and Effector B Cells: A New Path Toward Biomarkers and Therapeutic Targets to Improve Transplant Outcomes?

Aravind Cherukuri, Qing Ding, Akhil Sharma, Kanishka Mohib, David M Rothstein

Clinics in laboratory medicine 2019 Mar

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B cells shape the alloimmune response through polarized subsets. These cells inhibit or promote immune responses by expressing suppressive or proinflammatory cytokines. Their summed activity dictates the influence of B cells on the alloimmune response. We review the evidence for regulatory B cells and effector B cells in mice and humans, discuss current limitations in their phenotypic identification, and discuss regulatory B cells as a signature for clinical renal allograft tolerance and predictive markers for allograft outcomes. We discuss the effects of therapeutic agents on regulatory B cells and potential approaches to augment their numbers as a therapeutic tool. Copyright © 2018 Elsevier Inc. All rights reserved.

Citation

Aravind Cherukuri, Qing Ding, Akhil Sharma, Kanishka Mohib, David M Rothstein. Regulatory and Effector B Cells: A New Path Toward Biomarkers and Therapeutic Targets to Improve Transplant Outcomes? Clinics in laboratory medicine. 2019 Mar;39(1):15-29