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To establish the prevalence and risk factors for intravitreal dexamethasone implant migration into the anterior chamber in eyes with macular edema. This was a multicenter, retrospective, observational chart review of data that included patients with macular edema who had been treated with at least one intravitreal dexamethasone injection. Patients with incomplete chart information during the follow-up period were excluded. The prevalence of implant migration in 468 patients, considering the number of injections, was 1.6%, with significant associations between implant migration and cataract surgery (P = 0.043) and intraocular lens status (P = 0.005) and a trend toward statistical significance (P = 0.057) with vitrectomy. A higher rate of implant migration into the anterior chamber was observed in vitrectomized eyes (4.8%) when compared with patients who did not undergo a vitrectomy (1.6%). The implants that migrated were removed with forceps with/without viscoelastic expression or with 20-gauge cannulas connected to the vitreous cutter machine. The risk of implant migration into the anterior chamber was 1.6%. Risk factors were a history of cataract surgery or vitrectomy and aphakia. When anterior migration occurs, rapid removal is advised, especially if corneal edema is present.


Mariana Batista Gonçalves, Bruno de Queiroz Alves, Raphael Moura, Octaviano Magalhães, André Maia, Rubens Belfort, Marcos Pereira de Ávila, Marcelo Zas, Mario Saravia, Marcia Lousas, Lihteh Wu, J Fernando Arevalo, Katia Delalibera Pacheco, Taylor Johnson, Michel Eid Farah, Francisco Jose Rodriguez, Mauricio Maia, Pan-American Collaborative Retina Study Group. INTRAVITREAL DEXAMETHASONE IMPLANT MIGRATION INTO THE ANTERIOR CHAMBER: A Multicenter Study From the Pan-American Collaborative Retina Study Group. Retina (Philadelphia, Pa.). 2020 May;40(5):825-832

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PMID: 30789460

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