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To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Interventional case report and literature search. A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.


Osama M Mustafa, Yassine J Daoud. Corneoscleral xanthogranuloma treated with chemotherapy: The room for nonsurgical management. European journal of ophthalmology. 2020 Mar;30(2):NP23-NP26

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PMID: 30813780

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