Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission.

Sutisa Nudmamud-Thanoi, Sri-Arun Iamjan, Walailuk Kerdsan-Phusan, Samur Thanoi

Neuroscience letters 2020 May 01

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Multiple studies provide evidence to support dysfunction of glutamate neurotransmission in the pathogenesis of drug dependence. Pharmacogenetic investigation of glutamate-related genes has provided further support for the involvement of this neurotransmitter in the risk of, and consequences of, drug abuse and dependence. This paper aims to provide a brief review of these association studies. Findings involving single nucleotide polymorphisms (SNPs) in glutamate receptor genes (GRIN, GRIA) and glutamate transporter genes (SLC1A, SLC17A) are reviewed as potential risk factors. As yet a clear perspective of the functional consequences and interactions of the various reported findings is lacking. Copyright © 2019. Published by Elsevier B.V.

Citation

Sutisa Nudmamud-Thanoi, Sri-Arun Iamjan, Walailuk Kerdsan-Phusan, Samur Thanoi. Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission. Neuroscience letters. 2020 May 01;726:134128