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We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes, suggesting new potential roles for these helicases in disruption of quadruplex structures in RNA.

Citation

Jun Gao, Alicia K Byrd, Boris L Zybailov, John C Marecki, Michael J Guderyon, Andrea D Edwards, Shubeena Chib, Kirk L West, Zachary J Waldrip, Samuel G Mackintosh, Zhaofeng Gao, Andrea A Putnam, Eckhard Jankowsky, Kevin D Raney. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chemical communications (Cambridge, England). 2019 Apr 11;55(31):4467-4470

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PMID: 30855040

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