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    New asterosaponin, acanthaglycoside G (1), along with three previously known steroidal oligoglycosides (2‒4), were isolated from the ethanolic extract of the starfish Acanthaster planci, collected off the coast of Vietnam. The structure of 1 was mainly elucidated by extensive NMR and ESIMS techniques as sodium 6-O-{β-D-fucopyranosyl-(1→2)-β-D-quinovopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-quinovopyranosyl-(1→3)-β-D-quinovopyranosyl}-6α-hydroxy-5α-pregn-9(11)-en-20-one-3β-yl sulfate. Compounds 3 and 4 showed slight cytotoxic activities against cancer RPMI-7951, HT-29, and MDA-MB-231 cell lines, but effectively inhibited in non-toxic concentrations colony formation of HT-29 and MDA-MB-231 cells and cell migration of MDA-MB-231 cells. Compounds 1 and 2 were inactive or less active, respectively.


    Dinh T Ha, Alla A Kicha, Anatoly I Kalinovsky, Timofey V Malyarenko, Roman S Popov, Olesya S Malyarenko, Svetlana P Ermakova, Tran T T Thuy, Pham Q Long, Natalia V Ivanchina. Asterosaponins from the tropical starfish Acanthaster planci and their cytotoxic and anticancer activities in vitro. Natural product research. 2021 Feb;35(4):548-555

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    PMID: 30887834

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