The BARA necessities of PtdIns 3-kinase activation in autophagy.

Chunmei Chang, Lindsey N Young, James H Hurley

Autophagy 2019 Jun

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Macroautophagy/autophagy is an evolutionarily conserved degradation system with fundamental biological functions. The activation of the class III phosphatidylinositol 3-kinase (PtdIns3K) complexes and the subsequent production of phosphatidylinositol 3-phosphate (PtdIns3P) are pivotal to autophagy. Using a combination of structural biology, biochemistry, and biophysics, we revealed how the non-catalytic subunit BECN1 serves as a membrane-binding switch in the regulation of PtdIns3K complexes and autophagy.

Citation

Chunmei Chang, Lindsey N Young, James H Hurley. The BARA necessities of PtdIns 3-kinase activation in autophagy. Autophagy. 2019 Jun;15(6):1122-1123