Transient Receptor Potential Channels and Calcium Signaling.

Laura Vangeel, Thomas Voets

Cold Spring Harbor perspectives in biology 2019 Jun 03

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Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca2+ influx via voltage-gated and store-operated Ca2+ channels. Finally, Ca2+ modulates the activity of most TRP channels, allowing them to function as molecular effectors downstream of intracellular Ca2+ signals. Whereas the TRP channel field has long been devoid of detailed channel structures, recent advances, particularly in cryo-electron microscopy-based structural approaches, have yielded a flurry of TRP channel structures, including members from all seven subfamilies. These structures, in conjunction with mutagenesis-based functional approaches, provided important new insights into the mechanisms whereby TRP channels permeate and sense Ca2+ These insights will be highly instrumental in the rational design of novel treatments for the multitude of TRP channel-related diseases. Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.

Citation

Laura Vangeel, Thomas Voets. Transient Receptor Potential Channels and Calcium Signaling. Cold Spring Harbor perspectives in biology. 2019 Jun 03;11(6)