Blood Substitutes and Oxygen Therapeutics: A Review.

Jonathan S Jahr, Nicole R Guinn, David R Lowery, Linda Shore-Lesserson, Aryeh Shander

Anesthesia and analgesia 2021 Jan

filter terms:

Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood transfusion is not an option, due to patient's religious beliefs, inability to find adequately cross-matched erythrocytes, or in remote locations. In these situations, artificial oxygen carriers may provide a mortality benefit for patients with severe, life-threatening anemia. This article provides an up-to-date review of the history and development, clinical trials, new technology, and current standing of artificial oxygen carriers as an alternative to transfusion when blood is not an option.

Citation

Jonathan S Jahr, Nicole R Guinn, David R Lowery, Linda Shore-Lesserson, Aryeh Shander. Blood Substitutes and Oxygen Therapeutics: A Review. Anesthesia and analgesia. 2021 Jan;132(1):119-129