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    Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

    Citation

    Deanne M Taylor, Bruce J Aronow, Kai Tan, Kathrin Bernt, Nathan Salomonis, Casey S Greene, Alina Frolova, Sarah E Henrickson, Andrew Wells, Liming Pei, Jyoti K Jaiswal, Jeffrey Whitsett, Kathryn E Hamilton, Sonya A MacParland, Judith Kelsen, Robert O Heuckeroth, S Steven Potter, Laura A Vella, Natalie A Terry, Louis R Ghanem, Benjamin C Kennedy, Ingo Helbig, Kathleen E Sullivan, Leslie Castelo-Soccio, Arnold Kreigstein, Florian Herse, Martijn C Nawijn, Gerard H Koppelman, Melissa Haendel, Nomi L Harris, Jo Lynne Rokita, Yuanchao Zhang, Aviv Regev, Orit Rozenblatt-Rosen, Jennifer E Rood, Timothy L Tickle, Roser Vento-Tormo, Saif Alimohamed, Monkol Lek, Jessica C Mar, Kathleen M Loomes, David M Barrett, Prech Uapinyoying, Alan H Beggs, Pankaj B Agrawal, Yi-Wen Chen, Amanda B Muir, Lana X Garmire, Scott B Snapper, Javad Nazarian, Steven H Seeholzer, Hossein Fazelinia, Larry N Singh, Robert B Faryabi, Pichai Raman, Noor Dawany, Hongbo Michael Xie, Batsal Devkota, Sharon J Diskin, Stewart A Anderson, Eric F Rappaport, William Peranteau, Kathryn A Wikenheiser-Brokamp, Sarah Teichmann, Douglas Wallace, Tao Peng, Yang-Yang Ding, Man S Kim, Yi Xing, Sek Won Kong, Carsten G Bönnemann, Kenneth D Mandl, Peter S White. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental cell. 2019 Apr 08;49(1):10-29

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    PMID: 30930166

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