Human cells are permissive for the productive infection of porcine circovirus type 2 in vitro.

Xiaohui Liu, Ting Ouyang, Hongsheng Ouyang, Xiaohua Liu, Guyu Niu, Wang Huo, Weihong Yin, Daxin Pang, Linzhu Ren

Scientific reports 2019 Apr 04

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Porcine circovirus 2 (PCV2) is the main pathogen of porcine circovirus diseases and porcine circovirus-associated diseases, which are widespread in swine-producing countries. However, there is controversy regarding the susceptibility of human cells to PCV2 infection. In this study, human cell lines were infected with PCV2 and blind passaged several times. PCV2 entered and replicated in human cells, and infectious virions were generated, indicating that human cell lines were permissive to PCV2 replication. Furthermore, PCV2 replication in human cell lines was enhanced by D-glucosamine or concanavalin A (ConA). However, the infection efficiency of PCV2 was lower in human cells than in PK-15 cells, suggesting that PCV2 infection was limited in human cells. Our study reveals that human cells are permissive for the productive infection of porcine circovirus type 2 in vitro.

Citation

Xiaohui Liu, Ting Ouyang, Hongsheng Ouyang, Xiaohua Liu, Guyu Niu, Wang Huo, Weihong Yin, Daxin Pang, Linzhu Ren. Human cells are permissive for the productive infection of porcine circovirus type 2 in vitro. Scientific reports. 2019 Apr 04;9(1):5638