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The axon initial segment (AIS) comprises a sub-membranous lattice containing periodic actin rings. The overall AIS structure is insensitive to actin-disrupting drugs, but the effects of actin-disrupting drugs on actin rings lack consensus. We examined the effect of latrunculin A and B on the actin cytoskeleton of neurons in culture and actin rings in the AIS. Both latrunculin A and B markedly reduced the overall amount of F-actin in treated neurons in a dose-dependent manner, but the periodicity of actin rings remained unaffected. The insensitivity of AIS actin rings to latrunculin suggests they are relatively stable.


Amr Abouelezz, David Micinski, Aino Lipponen, Pirta Hotulainen. Sub-membranous actin rings in the axon initial segment are resistant to the action of latrunculin. Biological chemistry. 2019 Aug 27;400(9):1141-1146

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PMID: 30951495

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