A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat.

Lisha Yu, Xiaoqiang Shang, Hao Chen, Liping Xiao, Yihan Zhu, Jie Fan

Nature communications 2019 Apr 29

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Achieving rapid definitive hemostasis is essential to ensure survival of patients with massive bleeding in pre-hospital care. It is however challenging to develop hemostatic agents or dressings that simultaneously deliver a fast, long-lasting and safe treatment of hemorrhage. Here, we integrate meso-/micro-porosity, blood coagulation and stability into a flexible zeolite-cotton hybrid hemostat. We employ an on-site template-free growth route that tightly binds mesoporous single-crystal chabazite zeolite onto the surface of cotton fibers. This hemostatic material maintains high procoagulant activity after water flow treatment. Chabazite particles are firmly anchored onto the cotton surface with < 1% leaching after 10 min of sonication. The as-synthesized hemostatic device has superior hemostatic performance over most other clay or zeolite-based inorganic hemostats, in terms of higher procoagulant activity, minimized loss of active components and better scalability for practical applications (a hemostatic T-shirt is hereby demonstrated as an example).

Citation

Lisha Yu, Xiaoqiang Shang, Hao Chen, Liping Xiao, Yihan Zhu, Jie Fan. A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat. Nature communications. 2019 Apr 29;10(1):1932