Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier.

Jonathan J Ruprecht, Edmund Rs Kunji

Current opinion in structural biology 2019 Aug

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The mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase, accomplishes one of the most important transport activities in eukaryotic cells, importing ADP into the mitochondrial matrix for ATP synthesis, and exporting ATP to fuel cellular activities. In the transport cycle, the carrier changes between a cytoplasmic and matrix state, in which the central substrate binding site is alternately accessible to these compartments. A structure of a cytoplasmic state was known, but recently, a structure of a matrix-state in complex with bongkrekic acid was solved. Comparison of the two states explains the function of highly conserved sequence features and reveals that the transport mechanism is unique, involving the coordinated movement of six dynamic elements around a central translocation pathway. Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Jonathan J Ruprecht, Edmund Rs Kunji. Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier. Current opinion in structural biology. 2019 Aug;57:135-144