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In 2013 we established a cryo-electron microscopy (cryo-EM) technique called microcrystal electron diffraction (MicroED). Since that time, data collection and analysis schemes have been fine-tuned, and structures for more than 40 different proteins, oligopeptides and organic molecules have been determined. Here we review the MicroED technique and place it in context with other structure-determination methods. We showcase example structures solved by MicroED and provide practical advice to prospective users.


Brent L Nannenga, Tamir Gonen. The cryo-EM method microcrystal electron diffraction (MicroED). Nature methods. 2019 May;16(5):369-379

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PMID: 31040436

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