Synaptotagmins: Beyond Presynaptic Neurotransmitter Release.

Xuanang Wu, Shaoqin Hu, Xinjiang Kang, Changhe Wang

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2020 Feb

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Synaptotagmins (Syts) are well-established primary Ca2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly coupled exo-endocytosis, in presynapses. A recent study by Awasthi and others (2019) shows that Syt3 Ca2+-dependently modulates the postsynaptic receptor endocytosis and thereby promotes the long-term depression (LTD) and the decay of long-term potentiation (LTP). This work highlights the importance of Syt3 in modulating long-term synaptic plasticity and, importantly, extends the function of Syt proteins from presynaptic neurotransmitter release to a new promising postsynaptic receptor internalization.

Citation

Xuanang Wu, Shaoqin Hu, Xinjiang Kang, Changhe Wang. Synaptotagmins: Beyond Presynaptic Neurotransmitter Release. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2020 Feb;26(1):9-15