Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification.

Haitang Yang, Ying Li, Dingzhong Wang, Yong Liu, Wei Wei, Yuanjian Zhang, Songqin Liu, Peng Li

Chemical communications (Cambridge, England) 2019 May 28

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A novel circulating-flow quartz crystal microbalance (QCM) biosensing method has been established to detect telomerase. Oligonucleotide-functionalized gold nanoparticles (GNPs-cDNA) have been used to amplify the frequency change, which enable this QCM to be a sensitive biosensor for telomerase activity detection. The detection limit was as low as 37 cells per mL. The assay platform exhibited excellent selectivity.

Citation

Haitang Yang, Ying Li, Dingzhong Wang, Yong Liu, Wei Wei, Yuanjian Zhang, Songqin Liu, Peng Li. Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification. Chemical communications (Cambridge, England). 2019 May 28;55(43):5994-5997