Evaluation of Levels of Proinflammatory Chemokines MIP-1α and MIP-1β in Gingival Crevicular Fluid of Primary, Mixed and Permanent Dentition.

This study aims to find out the proinflammatory chemokines macrophage inflammatory protein (MIP)-1α and MIP-1β levels in gingival crevicular fluid (GCF) of primary, mixed, and permanent dentitions. GCF of 160 individuals (4-15 years of age) was collected by the extracrevicular method. They were categorized into four groups (40 per each group). Group I: subjects with primary dentition (4-5 years of age), Group II: 40 subjects in early transition period (6-8 years), Group III: 40 individuals in the late transition period (9-11 years), and Group IV: 40 individuals with permanent dentition (12-15 years). MIP-lα and MIP-1β levels were determined in the samples of GCF by ELISA method. Data were analyzed by software SPSS Version 20 (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY: USA). MIP-1α and MIP-1β were detected in all samples. The highest mean MIP-1α and MIP-1β concentrations in GCF were detected in the early transition period, while the lowest concentrations were seen in primary dentition group. The chemokine levels were higher in girls than in boys in Group III. There was a substantial rise of MIP-1α and MIP-1β levels during eruption. Since levels of MIP-1α and MIP-1β in GCF are positively associated with tooth eruption, they may perhaps be deemed as novel biomarkers in the eruption process.

Citation

B Swathi, Marisetty Charitha, Deepthi Mandava, Neeraj Tugaram, Durga Prasad Mudrakola, Ravishankar Yelamanchi. Evaluation of Levels of Proinflammatory Chemokines MIP-1α and MIP-1β in Gingival Crevicular Fluid of Primary, Mixed and Permanent Dentition. Journal of International Society of Preventive & Community Dentistry. 2019 Mar-Apr;9(2):205-209

PMID: 31058072

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