Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy.

Maria A Gubbiotti, Simone Buraschi, Aastha Kapoor, Renato V Iozzo

Seminars in cancer biology 2020 May

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The need for more effective cancer therapies is omnipresent as the ever-complex, and highly adaptive, mechanisms of tumor biology allow this disease to elude even the most stringent treatment options. The expanding field of proteoglycan signaling is enticing as a reservoir of potential drug targets and prospects for novel therapeutic strategies. The newest trend in proteoglycan biology is the interplay between extracellular signaling and autophagy fueled by the close link between autophagy and angiogenesis. Here we summarize the most current evidence surrounding proteoglycan signaling in both of these biological processes featuring the well-known suspects, decorin and perlecan, as well as other up-and-coming neophytes in this evolving signaling web. Copyright © 2019 Elsevier Ltd. All rights reserved.

Citation

Maria A Gubbiotti, Simone Buraschi, Aastha Kapoor, Renato V Iozzo. Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy. Seminars in cancer biology. 2020 May;62:1-8