A promiscuous kinase inhibitor reveals secrets to cancer cell survival.

Paul Shapiro

The Journal of biological chemistry 2019 May 24

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Deregulated kinase signaling networks drive the growth and survival of many cancer cells. However, the genetic complexity and rapidly evolving nature of most cancer cells create challenges when identifying the most relevant kinases to inhibit to achieve optimal therapeutic benefits. A new strategy that takes advantage of a well-characterized multitargeted kinase inhibitor describes a nongenetic approach to tease out key kinases that promote proliferation of specific cancer cell types. © 2019 Shapiro.

Citation

Paul Shapiro. A promiscuous kinase inhibitor reveals secrets to cancer cell survival. The Journal of biological chemistry. 2019 May 24;294(21):8674-8675