Correlation Engine 2.0
Clear Search sequence regions

  • cellular (1)
  • human (2)
  • nitrogen (4)
  • oxygen (4)
  • redox (2)
  • signal (1)
  • species (6)
  • sperm (2)
  • sulfur (4)
  • Sizes of these terms reflect their relevance to your search.

    Infertility is a significant global health problem that currently affects one of six couples in reproductive age. The quality of male reproductive cells dramatically decreased over the last years and almost every aspect of modern life additionally worsen sperm functional parameters that consequently markedly increase male infertility. This clearly points out the importance of finding a new approach to treat male infertility. Redox signaling mediated by reactive oxygen, nitrogen and sulfur species (ROS, RNS, and RSS respectively), has appeared important for sperm reproductive function. Present review summarizes the current knowledge of ROS, RNS, and RSS in male reproductive biology and identifies potential targets for development of novel pharmacological and therapeutic approaches for male infertility by targeted therapeutic modulation of redox signaling. © 2019 International Union of Biochemistry and Molecular Biology.


    Vesna Otasevic, Ana Stancic, Aleksandra Korac, Aleksandra Jankovic, Bato Korac. Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology. BioFactors (Oxford, England). 2020 Mar;46(2):206-219

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31185138

    View Full Text