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The structure of WF-3681, a novel aldose reductase inhibitor produced by Chaetomella raphigera Swift No. 3681, was deduced to be 1 on the basis of its spectroscopic and chemical evidences and confirmed by a total synthesis starting from (E)-5-phenyl-4-pentenol.

Citation

T Namiki, M Nishikawa, Y Itoh, I Uchida, M Hashimoto. Studies on WF-3681, a novel aldose reductase inhibitor. II. Structure determination and synthesis. The Journal of antibiotics. 1987 Oct;40(10):1400-7

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PMID: 3119548

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