Refractory THSD7A membranous nephropathy with severe asthma related to eosinophilia .

Tomo Suzuki, Shu Ushimaru, Daisuke Uchida, Shiika Watanabe, Daisuke Ichikawa, Junki Koike, Hidehiko Mizuguchi, Hiroo Kawarazaki, Yugo Shibagaki

Clinical nephrology 2019 Aug

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We report a case of a 50-year-old Japanese man with a history of pediatric asthma diagnosed with nephrotic syndrome after 4 years of relapsing asthma with severe eosinophilia. Thrombospondin type-1 domain-containing 7A membranous nephropathy (THSD7A-MN) was diagnosed based on histological evaluation. We started a course of steroid semi-pulse therapy, high-dose oral prednisolone, mizoribine, and cyclosporine. Frequent relapse of asthma was observed after gradual tapering of prednisolone dose to 10 mg/day. After improvement of asthma symptoms and eosinophilia, his serum albumin level increased gradually. Considering the clinical course of refractory MN and asthma, we suggest that THSD7A-MN may be associated with severe asthma and eosinophilia.

Citation

Tomo Suzuki, Shu Ushimaru, Daisuke Uchida, Shiika Watanabe, Daisuke Ichikawa, Junki Koike, Hidehiko Mizuguchi, Hiroo Kawarazaki, Yugo Shibagaki. Refractory THSD7A membranous nephropathy with severe asthma related to eosinophilia . Clinical nephrology. 2019 Aug;92(2):103-108