Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica.

Six new pyrrole 2-carbaldehyde derived alkaloids, dahurines A-F (1-6), along with five known ones (7-11) and butyl 2-pyrrolidone-5-carboxylate (12) were isolated from the roots of Angelica dahurica. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) methods. Although compounds 7 and 8 have been chemically synthesized, they were obtained from natural materials for the first time. Compounds 2, 3, 4, 10, and 11 exhibited acetylcholinesterase inhibitory activity with IC50 values in the range of 47.5-52.5 μM. Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica.

Citation

Bowen Qi, Wanqing Yang, Ning Ding, Yuan Luo, Fangfang Jia, Xiao Liu, Juan Wang, Xiaohui Wang, Pengfei Tu, Shepo Shi. Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica. Journal of natural medicines. 2019 Sep;73(4):769-776

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PMID: 31209724

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