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JmjC histone demethylases act as chromatin oxygen sensors.
Molecular & cellular oncology 2019Sizes of these terms reflect their relevance to your search.
Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.
Citation
Michael Batie, Sonia Rocha. JmjC histone demethylases act as chromatin oxygen sensors. Molecular & cellular oncology. 2019;6(4):1608501
PMID: 31211238
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