Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.

Paul J Harrison, Elizabeth M Tunbridge, Annette C Dolphin, Jeremy Hall

The British journal of psychiatry : the journal of mental science 2020 May

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We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.

Citation

Paul J Harrison, Elizabeth M Tunbridge, Annette C Dolphin, Jeremy Hall. Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal. The British journal of psychiatry : the journal of mental science. 2020 May;216(5):250-253