Acute pulmonary thromboembolism caused by factor V Leiden mutation in South Korea: A case report.

Medicine 2019 Jul

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Although Factor V Leiden (FVL) mutation is a major cause of inherited thrombophilia in Western populations; the mutation is extremely rare in Asia. Here we report a case of a 28-year old Korean woman admitted to our hospital with extensive pulmonary embolism. She was heterozygous for FVL mutation up on evaluation, and screening for asymptomatic family members also revealed heterozygous FVL mutation for her mother. Enoxaparin 1 mg/kg was initiated, followed by rivaroxaban 15 mg every 12 hours. The patient showed improvement in both subjective dyspnea and right ventricular dysfunction and was successfully discharged after five hospital days. FVL mutation screening may be considered in Asian patients with thrombophilia of uncertain etiology in the future.

Citation

Hun Jee Choe, Koung Jin Suh, Ji Yun Lee, Minyoung Kim, Man Jin Kim, Sung Sup Park, Ji-Won Kim, Se Hyun Kim, Jin Won Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee. Acute pulmonary thromboembolism caused by factor V Leiden mutation in South Korea: A case report. Medicine. 2019 Jul;98(28):e16318