Driving tau into phase-separated liquid droplets.

Martin Margittai

The Journal of biological chemistry 2019 Jul 19

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Liquid-liquid phase separation of tau protein has been implicated in normal biological function as well as neurodegenerative diseases, including Alzheimer's. However, knowledge about these links is still scant, and the mechanisms driving tau into liquid droplets are poorly understood. A simplified in vitro system that uses unmodified human tau protein now suggests electrostatic interactions provide the basic instructions underlying liquid droplet formation. © 2019 Margittai.