Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes.

Michelle S M A Damen, Dov Ballak, Zackary Sapinsley, Xiyuan Bai, Edward D Chan, Douglas R Seals, Calin D Popa, Leo A B Joosten

Cytokine 2020 Jan

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Low-grade inflammation is associated with the development of insulin resistance in obese individuals. The present study aims to provide additional evidence strengthening the role of interleukin (IL)-32 in this key process. Using an IL-32 transgenic (IL-32tg) mouse model, we observed that IL-32tg fed a normal diet had greater body weight, due to greater accumulation of white adipose tissue (WAT) along with larger sized adipocytes. This led to metabolic consequences, with significant higher leptin levels and a trend towards hyperinsulinemia, indicating a phenotype resembling the metabolic syndrome. Adipocytes of IL-32tg mice were more prone to induce a pro-inflammatory response locally, which would be expected when predisposed to insulin resistance and type2 diabetes mellitus (T2D). In conclusion, our study provides novel evidence of a direct contribution of IL-32 to pathophysiological perturbations within the adipose tissue, possibly contributing to the metabolic syndrome that precedes frank insulin resistance and T2D. Future research should focus on the role of IL-32 in the obesity epidemic. Copyright © 2019 Elsevier Ltd. All rights reserved.

Citation

Michelle S M A Damen, Dov Ballak, Zackary Sapinsley, Xiyuan Bai, Edward D Chan, Douglas R Seals, Calin D Popa, Leo A B Joosten. Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes. Cytokine. 2020 Jan;125:154793