Counter-regulatory renin-angiotensin system in cardiovascular disease.

Maria Paz Ocaranza, Jaime A Riquelme, Lorena García, Jorge E Jalil, Mario Chiong, Robson A S Santos, Sergio Lavandero

Nature reviews. Cardiology 2020 Feb

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The renin-angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II - initially thought to be biologically inactive - have key roles in cardiovascular physiology and pathophysiology. This non-canonical axis of the renin-angiotensin system consists of angiotensin 1-7, angiotensin 1-9, angiotensin-converting enzyme 2, the type 2 angiotensin II receptor (AT2R), the proto-oncogene Mas receptor and the Mas-related G protein-coupled receptor member D. Each of these components has been shown to counteract the effects of the classical renin-angiotensin system. This counter-regulatory renin-angiotensin system has a central role in the pathogenesis and development of various cardiovascular diseases and, therefore, represents a potential therapeutic target. In this Review, we provide the latest insights into the complexity and interplay of the components of the non-canonical renin-angiotensin system, and discuss the function and therapeutic potential of targeting this system to treat cardiovascular disease.

Citation

Maria Paz Ocaranza, Jaime A Riquelme, Lorena García, Jorge E Jalil, Mario Chiong, Robson A S Santos, Sergio Lavandero. Counter-regulatory renin-angiotensin system in cardiovascular disease. Nature reviews. Cardiology. 2020 Feb;17(2):116-129