Ozone and pulsed electro-magnetic field therapies improve endometrial lining thickness in frozen embryo transfer cycles: Three case reports.

Zaher Merhi, Rajean Moseley-LaRue, Amber Ray Moseley, André Hugo Smith, John Zhang

Medicine 2019 Aug

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In assisted reproductive technology, a persistently thin endometrial lining represents a huge challenge during frozen embryo transfer (FET) cycles. Three patients who had a persistently thin endometrial lining despite the use of several medical agents known to improve endometrial lining thickness. Infertility undergoing FET cycles. A combination of transdermal and intravaginal ozone therapy along with Pulsed Electro-Magnetic Field (PEMF) therapy. Ozone with PEMF, both of which are known to have vasodilatatory, anti-inflammatory, and anti-oxidant actions, were successful in improving the thickness of the endometrial lining in all 3 patients. Two out of 3 patients became pregnant following single embryo transfer. Ozone with PEMF constitute a novel experimental approach for women with persistently thin endometrial lining undergoing FET. This novel approach needs validation by large well-designed studies.

Citation

Zaher Merhi, Rajean Moseley-LaRue, Amber Ray Moseley, André Hugo Smith, John Zhang. Ozone and pulsed electro-magnetic field therapies improve endometrial lining thickness in frozen embryo transfer cycles: Three case reports. Medicine. 2019 Aug;98(34):e16865