Correlation Engine 2.0
Clear Search sequence regions

  • blood (1)
  • cytokines (1)
  • dna damage (1)
  • gentamicin (14)
  • gentamicin b (2)
  • IFN γ (1)
  • IL 1β (1)
  • lipid (1)
  • mrna (1)
  • necrosis (1)
  • nitric oxide (1)
  • rats (6)
  • rats wistar (1)
  • serum (2)
  • TNF α (1)
  • Sizes of these terms reflect their relevance to your search.

    The present study was considered to assess the protective effects of boron (B) on gentamicin-induced oxidative stress, proinflammatory cytokines, and histopathological changes in rat kidneys. Rats were split into eight equal groups which were as follows: control (fed with low-boron diet); gentamicin group (100 mg/kg, i.p.); B5, B10, and B20 (5, 10, and 20 mg/kg B, i.p.) groups; gentamicin (100 mg/kg, i.p.) plus B5, B10, and B20 (5, 10, and 20 mg/kg B, i.p.) groups. B was given to rats 4 days before the gentamicin treatment and B administration was completed on the 14th day. Gentamicin administration was started on the 4th day and finished on the 12th day. Gentamicin increased malondialdehyde levels, while reduced glutathione levels in the blood and kidney. Furthermore, superoxide dismutase and catalase activities of erythrocyte were decreased. Besides, serum and kidney nitric oxide and 8-dihydroxyguanidine levels were increased by gentamicin. Additionally, serum levels and kidney mRNA expressions of TNF-α, NFκB, IL-1β, and IFN-γ were found to be the highest in the gentamicin group. Histopathologically, interstitial hemorrhage and tubular necrosis were detected in the kidneys of the gentamicin group. Nonetheless, B administration reversed gentamicin-induced lipid peroxidation, antioxidant status, and inflammation. In conclusion, B has a preventive effect against gentamicin-induced nephrotoxicity and ameliorates kidney tissues of the rat.


    Sinan Ince, Ismail Kucukkurt, Hasan Huseyin Demirel, Damla Arslan-Acaroz, Nuray Varol. Boron, a Trace Mineral, Alleviates Gentamicin-Induced Nephrotoxicity in Rats. Biological trace element research. 2020 Jun;195(2):515-524

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31446563

    View Full Text