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Hyponatraemia is common in heart failure (HF). It is estimated that over 20% of patients admitted to hospital with HF have hyponatraemia. It has also been repeatedly shown to be a surrogate marker of increased morbidity and mortality in this specific population. This review focuses on the pathophysiology of hyponatraemia through the activation of neurohormonal cascades in HF, the clinical implications of sustained hyponatraemia and treatment options in the management of this challenging phenomenon. © 2019 Royal Australasian College of Physicians.


Su Ling Tee, Andrew Sindone, Simon Roger, John Atherton, John Amerena, Michael D'Emden, Jonathan Erlich, Carmine De Pasquale. Hyponatraemia in heart failure. Internal medicine journal. 2020 Jun;50(6):659-666

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PMID: 31449715

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