From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides.

Steffen Köcher, Sarah Resch, Till Kessenbrock, Lukas Schrapp, Michael Ehrmann, Markus Kaiser

Natural product reports 2020 Feb 26

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Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. Here, we review their isolation and structural elucidation from natural sources as well as studies of their biosynthesis, molecular mode of action, and use in drug discovery efforts. Accordingly, this summary aims to provide a comprehensive overview of the current state-of-the-art Ahp-cyclodepsipeptide research.

Citation

Steffen Köcher, Sarah Resch, Till Kessenbrock, Lukas Schrapp, Michael Ehrmann, Markus Kaiser. From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides. Natural product reports. 2020 Feb 26;37(2):163-174