Kang Huang, Jianghua Zhong, Qiang Li, Wei Zhang, Zibin Chen, Yilei Zhou, Miao Wu, Zanrui Zhong, Shijuan Lu, Shufang Zhang
Molecular genetics & genomic medicine 2019 NovCoronary heart disease (CHD) is one of the most severe cardiovascular diseases. Cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) is a significant susceptibility locus for cardiovascular disease by regulating inflammation response and cell cycle. The aim of this study was to assess whether CDKN2B-AS1 polymorphisms are associated with CHD risk in the Chinese Han population. A total of 501 CHD patients and 496 healthy controls were recruited from Central South University Xiangya School of Medicine Affiliated Haikou Hospital, five CDKN2B-AS1 polymorphisms (rs10115049, rs75227345, rs2383205, rs10738606, and rs1333049) were analyzed by the Agena MassARRAY platform. The association of CDKN2B-AS1 polymorphisms and CHD risk was determined by odd ratios (OR) and 95% confidence intervals (CI) using logistic regression. CDKN2B-AS1 rs10738606 was significantly associated with CHD under codominant (p = .03), dominant (p = .019), recessive (p = .010), additive (p = .003), and allele (p = .003) models. Gender-based subgroup tests showed that four polymorphisms (rs75227345, rs2383205, rs10738606 and rs1333049) were associated with CHD in males (p < .05). And age-based subgroup tests indicated that rs2383205 and rs10738606 were associated with CHD among individuals, respectively (p < .05). For CHD patients, rs1333049 decreased the risk of diabetes under heterozygote (p = .014) and dominant (p = .024) models. In conclusion, CDKN2B-AS1 polymorphisms were associated with CHD risk in the combined or subgroup tests, suggesting an important role of CDKN2B-AS1 in CHD susceptibility. © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.
Kang Huang, Jianghua Zhong, Qiang Li, Wei Zhang, Zibin Chen, Yilei Zhou, Miao Wu, Zanrui Zhong, Shijuan Lu, Shufang Zhang. Effects of CDKN2B-AS1 polymorphisms on the susceptibility to coronary heart disease. Molecular genetics & genomic medicine. 2019 Nov;7(11):e955
PMID: 31496134
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