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New chymotrypsin inhibitory peptides named streptopeptolins B and C were isolated from Streptomyces olivochromogenes. Structures of streptopeptolins B and C were determined to be cyclic depsipeptides possessing 3-amino-6-hydroxy-2-piperidone unit by interpretation of NMR spectra and ESI-MS. Streptopeptolins B and C showed inhibitory activities to chymotrypsin with IC50 of 8.0 and 12.0 μg/mL, respectively.

Citation

Ankit Tiwari, Issara Kaweewan, Yuto Miyake, Hikaru Hemmi, Shinya Kodani. Isolation and structure determination of new chymotrypsin inhibitory peptides streptopeptolins B and C. Natural product research. 2021 Aug;35(16):2700-2706

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PMID: 31512511

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