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    Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing, yet a complete census of its cell types and connectivity remains elusive. Using whole-cell recordings with morphological recovery, we identified one major excitatory and seven inhibitory types of neurons in L4 of adult mouse visual cortex (V1). Nearly all excitatory neurons were pyramidal and all somatostatin-positive (SOM+) non-fast-spiking interneurons were Martinotti cells. In contrast, in somatosensory cortex (S1), excitatory neurons were mostly stellate and SOM+ interneurons were non-Martinotti. These morphologically distinct SOM+ interneurons corresponded to different transcriptomic cell types and were differentially integrated into the local circuit with only S1 neurons receiving local excitatory input. We propose that cell type specific circuit motifs, such as the Martinotti/pyramidal and non-Martinotti/stellate pairs, are used across the cortex as building blocks to assemble cortical circuits.

    Citation

    Federico Scala, Dmitry Kobak, Shen Shan, Yves Bernaerts, Sophie Laturnus, Cathryn Rene Cadwell, Leonard Hartmanis, Emmanouil Froudarakis, Jesus Ramon Castro, Zheng Huan Tan, Stelios Papadopoulos, Saumil Surendra Patel, Rickard Sandberg, Philipp Berens, Xiaolong Jiang, Andreas Savas Tolias. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Nature communications. 2019 Sep 13;10(1):4174

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    PMID: 31519874

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