Oral adverse effects of drugs: Taste disorders.

Willem Maria Hubertus Rademacher, Yalda Aziz, Atty Hielema, Ka-Chun Cheung, Jan de Lange, Arjan Vissink, Frederik Reinder Rozema

Oral diseases 2020 Jan

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Oral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug-induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision making whether a taste disorder can be due to use of drugs by providing a comprehensive overview of drugs with taste disorders as an adverse effect. The national drug information database for Dutch pharmacists, based on scientific drug information, guidelines, and summaries of product characteristics, was analyzed for drug-induced taste disorders. "MedDRA classification" and "Anatomic Therapeutical Chemical codes" were used to categorize the results. Of the 1,645 drugs registered in the database, 282 (17%) were documented with "dysgeusia" and 61 (3.7%) with "hypogeusia." Drug-induced taste disorders are reported in all drug categories, but predominantly in "antineoplastic and immunomodulating agents," "antiinfectives for systemic use," and "nervous system." In ~45%, "dry mouth" coincided as adverse effect with taste disorders. Healthcare professionals are frequently confronted with drugs reported to cause taste disorders. This article provides an overview of these drugs to support clinicians in their awareness, diagnosis, and treatment of drug-induced taste disorders. © 2019 Vrije Universiteit Amsterdam. Oral Diseases published by John Wiley & Sons Ltd.

Citation

Willem Maria Hubertus Rademacher, Yalda Aziz, Atty Hielema, Ka-Chun Cheung, Jan de Lange, Arjan Vissink, Frederik Reinder Rozema. Oral adverse effects of drugs: Taste disorders. Oral diseases. 2020 Jan;26(1):213-223