Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.

Inflammation has been shown to accompany Metabolic Syndrome (MetS) and its features. Cathepsin D is one of a proinflammatory mediator. In the current study, we aimed to investigate the effect of curcumin supplementation on serum cathepsin D levels in patients with MetS. The current study was conducted on 18-65 years old individuals with MetS diagnosed according to the International Diabetes Federation guidelines. A total of 80 participants were randomly divided into treatment and control groups. The first group (n=40) was given 2 capsules containing 500 mg of phosphatidylcholine complex of curcumin, and the other group (n=40) was given two 500 mg placebo capsules for 6 weeks. Before (week 0) and after (week 6) the intervention, anthropometric indices and blood pressure were measured and blood samples were taken. Serum cathepsin D was measured using an ELISA kit. There was no significant difference between treatment and control groups in terms of weight, body mass index, waist circumference and serum cathepsin D levels before and after the intervention. In addition, there was no significant difference between pre- and post-trial values of serum cathepsin D. The present results do not suggest any effect of curcumin on cathepsin D levels in patients with MetS. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Leila Shirmohammadi, Majid Ghayour-Mobarhan, Maryam Saberi-Karimian, Mehrdad Iranshahi, Shima Tavallaie, Marzieh Emamian, Amirhossein Sahebkar. Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome. Cardiovascular & hematological disorders drug targets. 2020;20(2):116-121

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PMID: 31538907

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